Infliximab Management Complex Regional Pain Syndrome
نویسنده
چکیده
The role of inflammatory mechanisms in the pathogenesis of CRPS is important and that makes it a target that must meet every day. Infliximab is a molecule that has been used in the management of CRPS and published case reports and two studies showing improvement in range of motion, differences in temperature and decrease pain persist even phenomena of peripheral and Central after a few months; as same adverse reactions have been reported including appearance of CRPS in patients who received other necessary conditions and use with caution. The information is so far low level of evidence for such studies from which it was generated so it is necessary to have higher quality studies to obtain more solid conclusions.
منابع مشابه
Successful intravenous regional block with low-dose tumor necrosis factor-alpha antibody infliximab for treatment of complex regional pain syndrome 1.
Cytokines, particularly tumor necrosis factor-alpha, may play an important role in the mediation of mechanical hyperalgesia and autonomic signs in complex regional pain syndrome 1. We performed an IV regional block with low-dose administration of the tumor necrosis factor-alpha antibody, infliximab, in a patient with typical clinical signs of complex regional pain syndrome 1 (moderate pain, ede...
متن کاملReport of a preliminary discontinued double-blind, randomized, placebo-controlled trial of the anti-TNF-α chimeric monoclonal antibody infliximab in complex regional pain syndrome.
OBJECTIVE Inflammation appears to play a role in CRPS as, for example, cytokines (like TNF-α) are involved in the affected limb. The ongoing inflammation is probably responsible for the central sensitization that sometimes occurs in CRPS. Thus, early start of a TNF-α antagonist may counteract inflammation, thereby preventing rest damage and leading to recovery of the disease. DESIGN Patients ...
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Complex regional pain syndrome is a severe chronic pain condition. Its diagnosis to date is controversial. Effects of various treatment methods also remain controversial with unpredictable outcomes. The author experienced a case of complex regional pain syndrome type 2 which was cured by sympathetic blockade and myofascial trigger point injection. Afterwards, the author focused on myofascial tr...
متن کاملTargeting oxidative injury and cytokines' activity in the treatment with anti-tumor necrosis factor-α antibody for complex regional pain syndrome 1.
Cytokines and oxygen free radicals have been implicated in the potential pathogenic development of complex regional pain syndrome (CRPS). We aimed to analyze the relationship between clinical status, circulating levels of cytokines, and markers of oxidative damage during the treatment with anti-TNFα antibodies. The patient chosen for treatment had not had improvement through a number of convent...
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Complex Regional Pain Syndrome is a painful debilitating condition characterised by sensory, vasomotor, sudomotor, and trophic changes. Traditionally, physiotherapy treatments have been directed at peripheral symptoms, often with limited efficacy. In light of the growing scientific evidence promoting the major role of the central nervous system in the pathogenesis of Complex Regional Pain Syndr...
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تاریخ انتشار 2015